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How Ledermix Is Different

Ledermix is the only clinically proven product that has a long history of effective root canal management. It is essential for dental professionals who want to reduce the pain for their patients and be known for providing a service using reliable, superior products that are globally endorsed. We have invested heavily in ensuring the availability of an Australian made product and are fully committed to providing the leading product that provides greater benefits.
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Ledermix holds a long history of providing reliable treatment

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Ledermix has clinically proven results

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Ledermix is endorsed by key opinion leaders and experts

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Ledermix™ Paste

Ledermix™ Paste  is indicated for use as an intracanal medicament in teeth undergoing
root canal treatment5,6 in the following situations:

Acute irreversible pulpitis.

Acute apical periodontitis due to an infected root canal system. Other medicaments then need to be used as subsequent dressings (e.g. calcium hydroxide) to ensure maximum disinfection since the demeclocycline has a limited antibacterial spectrum of activity.

​Inflammatory root resorption - both internal and external - as the initial dressing when the resorption is established. Other medicaments then need to be used as subsequent dressings (e.g. calcium hydroxide) to promote hard tissue repair.

To prevent the development of inflammatory resorption10,11,35 following avulsion of fully developed teeth and other injuries (e.g. intrusion of fully developed teeth) where this type of resorption is likely to occur. Its use in these situations may also reduce the amount of replacement resorption that can occur following these injuries.35

To reduce post-operative pain by reducing the periapical inflammation.7,8 If the pain is associated with an infected root canal system, then other medicaments then need to be used as subsequent dressings (e.g. calcium hydroxide) to ensure maximum disinfection since the demeclocycline has a limited antibacterial spectrum of activity.

To inhibit & reduce the number of bacteria within infected root canals. Other medicaments then need to be used as subsequent dressings (e.g. calcium hydroxide) to ensure maximum disinfection since the demeclocycline has a limited antibacterial spectrum of activity.

Ledermix™ Paste can also be used as a pulpotomy agent in the emergency management of acute irreversible pulpitis5,6 - in these cases, it should only be used as an interim pain relief measure that must be followed by more comprehensive treatment such as pulpectomy and root canal therapy.

Click for downloadable Product MSDS PDF

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Recommended for endodontic use

Ledermix™ has long been used for its antibacterial and anti-inflammatory properties. In recent years, Ledermix™ has gained much attention in dental traumatology as there is increasing evidence that it can inhibit inflammatory root resorption after severe lunation and avulsion injuries.
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Backed by peer-reviewed studies

Ledermix™ Paste
"More than 85% of cases had complete relief of pain after a one-hour interval and more than 93% were free of pain within 24 hours of treatment."1
1. Negem MM. Intercanal use of a corticosteroid-antibiotic compound for the management of post-treatment endodontic pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92:435-439.
Ledermix™ Cement
"Provided there is an accurate diagnosis of the pulp status and its cause, teeth with reversible pulpits due to cracks can be treated conservatively without endodontic treatment in about 80% of cases."2
2. P Abbott,*N Leow*, Predictable management of cracked teeth with reversible pulpitis, Australian Dental Journal 2009;54:306-315
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The superior choice on the market

Ledermix™ is the superior choice as other medicaments have no publications in peer-reviewed journals that support their antibacterial or anti-inflammatory efficacy, or their ability to inhibit inflammatory root resorption after severe lunation and avulsion injuries
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Information For Use

In general, Ledermix™ Paste has two main therapeutic actions as a result of its two active components – one reduces inflammation whilst the other reduces the viable microbial flora within the root canal system. A further therapeutic action is by inhibition of clastic cells when managing inflammatory root resorption.

The pain associated with pulp and periapical diseases is a result of inflammation of the pulp and/or periapical tissues. Hence, in order to reduce the patient’s pain, it is essential to remove the cause of the inflammation.6 In addition, reduction of the inflammatory reaction will help to reduce pain more rapidly
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Ledermix™ Cement

Ledermix™ Cement is a hard-setting material for use on dentine as a lining, as a pulp capping agent and as a pulpotomy agent.16 This material is presented as a powder and a liquid that must be mixed immediately prior to use in a tooth.28 There are two forms of the liquid component – a fast-setting formulation and a normal setting formulation – and the majority of the liquid is eugenol (85%).27,28 The powder component contains zinc oxide (47.2%) and calcium hydroxide with the latter making up 33.4% of the powder.27 Once the powder and liquid are mixed, the cement is a zinc oxide-eugenol cement containing triamcinolone, demeclocycline and calcium hydroxide as its active ingredients.27

16. Hume WR, Kenney AE. Release of 3H-triamcinolone
from Ledermix. J Endod 1981;7:509-14.

27. Abbott PV, Leow N. Predictable management of cracked
teeth with reversible pulpitis. Aust Dent J 2009;54:306-315.

28. Lederle Laboratories. Product pamphlet accompanying
“Ledermix”. Wolfratshausen 1962.
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Ledermix™ Cement

Ledermix™ Cement is indicated for use15,16,27,38-44 in the following
situations:
  • For the management of reversible pulpitis in both deciduous and permanent teeth by indirect pulp capping – that is, where there has not been a pulp exposure.
  • For the management of reversible pulpitis in both deciduous and permanent teeth by direct pulp capping or as a pulpotomy agent where the pulp has been exposed.
15. Schroeder A. Corticosteroids in endodontics. J Oral Therap Pharmacol 1965;2171-9.

16. Hume WR, Kenney AE. Release of 3H-triamcinolone from Ledermix. J Endod 1981;7:509-14.
27. Abbott PV, Leow N. Predictable management of cracked teeth with reversible pulpitis. Aust Dent J
2009;54:306-315.
38. Schroeder A. Indirect capping and the treatment of deep carious lesions. Int Dent J 1968;18:381-91.
39. Ehrmann EH. The effect of triamcinolone with tetracycline on the dental pulp and apical periodontium. J Prosthet Dent 1965;15:149-52.
40. Clarke NG. The corticosteroid-antibiotic dressing as a capping for inflamed dental pulps. Aust Dent J 1971;16:71-6.
41. Schroeder A. The problem of direct pulp capping. J Brit Endod Soc 1972;6:72-9.
42. Ehrmann EH. The endodontic management of the
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Ledermix™ Cement

  • Use as a lining or indirect pulp capping material in asymptomatic teeth with deep carious cavities prior to placing a restoration in order to reduce the inflammation that may have been present due to the caries and also to reduce the inflammatory effects of the operative procedures.
  • Use to cement interim crowns following preparation of the tooth for a crown restoration in order to reduce the inflammatory effects of the operative procedures.
  • Use as a root filling material in deciduous teeth with irreversible pulpitis or an infected root canal system following thorough canal cleaning and preparation.
43. Barker BCW. Conservative treatment of cariously exposed vital pulps in posterior teeth with aglucocorticosteroid-antibiotic compound. J Brit Endod Soc 1975;8:5-15.
44. Ehrmann EH. Pulpotomies in traumatized and carious permanent teeth using corticosteroid antibiotic preparation. Int Endod J 1981;14:149-56.
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Ledermix™ study

Ledermix™ Cement has been shown to release triamcinolone which then diffuses through the dentine to reach the pulp space.

16 Approximately 70% of the triamcinolone is released by the end of the first day and the remainder is released by the end of the third day following application to a cavity floor.16 The results of this in vitro study are consistent with a clinical study27 of the use of Ledermix cement as an indirect pulp capping or lining material in 85 teeth with reversible pulpitis due to the presence of cracks in the teeth.
16. Hume WR, Kenney AE. Release of 3H-triamcinolone from Ledermix. J Endod 1981;7:509-14.
27. Abbott PV, Leow N. Predictable management of cracked teeth with reversible pulpitis. Aust Dent J
2009;54:306-315.
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Ledermix™ results

After the removal of the crack and caries followed by the placement of Ledermix™ Cement and an interim glass ionomer restoration, complete resolution of symptoms occurred immediately in 71% of the patients. A further 21% of cases had resolution of the symptoms within 1 day, 6% took

2 days and 3% took 3 days. On follow-up after three months, 97.6% of teeth treated with Ledermix™ Cement had their Reversible Pulpitis resolved.
16. Hume WR, Kenney AE. Release of 3H-triamcinolone from Ledermix. J Endod 1981;7:509-14.
27. Abbott PV, Leow N. Predictable management of cracked teeth with reversible pulpitis. Aust Dent J
2009;54:306-315.
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Application Methods

The application of preparation which has been used and well known for over 50 years, Ledermix™ Paste is what is called for. Due to the active substance, triamcinolone, Ledermix™ Paste counteracts pain symptoms promptly and quickly and leads to significant improvement.
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